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The new second class of BTK inhibitors are having more specificity for their targets, i.e., Tirabrutinib (ONO-4059), GDC-0834, Spebrutinib, CNX-774, Acalabrutinib (ACP-196), tolebrutinib (Sanofi), evobrutinib (Merck), acalabrutinib (Astra Zeneca), orelabrutinib (Innocare), remibrutinib (Novartis) and many more are under various preclinical and clinical phases in the arthritis patients [87]

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